What is Dammarane aglycone

Dammarane aglycone (Dammarane Sapogenin) is a group of dammarane saponins to glycosylated compounds. Dammarane aglycone injection.Dammarane aglycones are present in a class of Araliaceae in a group of compounds, dammarane for the skeleton, is a tetracyclic triterpenoid structure. In China and Asian countries for thousands of years, with this component of the plant (such as ginseng) has been prescribed in Chinese medicine is an important component, and is widely used. Table Ming Dama latest research alkyl aglycone is ideal for a group of anti-cancer compounds.
Effect

1. dammarane daidzein inhibit cancer cell proliferation and induce their differentiation into benign.
2. dammarane aglycone via a variety of mechanisms to promote cancer cell into a suicidal cell death program (apoptosis), and are usually within this program is turned off in cancer cells.
3. dammarane daidzein inhibit cancer cells on P-glycoprotein (P-gp) protein; and P-gp protein in multidrug resistance of cancer cells is caused by one of the main. When chemotherapy combined with dammarane aglycone when used with the P-gp protein was inhibited, the efficacy of chemotherapy drugs can be significantly improved.
4. dammarane aglycone and the body of some of the P450s enzyme interactions, to reduce cancer-causing substances in the environment due to induced cancer incidence.
5. dammarane aglycones can compete with estrogen receptor; reduce estrogen binding to its receptor, and removed the effect of estrogen on tumor growth stimulation.

Practical application

• A large number of experimental evidence Ming Dama alkyl aglycone at low doses to inhibit abnormal cells (tumor cells) division, and induction of abnormal cells (cancer cells) differentiate benign;
• Large doses dammarane aglycones induced by multiple mechanisms shaped cells (tumor cells) apoptosis;
• Dammarane daidzein can effectively block the function of p-gp protein to reverse the abnormal cells (tumor cells) of drug resistance.

Basic and clinical studies confirm that dammarane daidzein can induce differentiation of mesenchymal stem cells into organs, including skin cells, fibroblasts, neural stem cells, progenitor cells and hematopoietic stem cells. Table Ming Dama alkyl aglycone experiment in vitro to promote human monocyte differentiation and maturation of dendritic cells. After daidzein treatment dammarane dendritic cells (DCs) to enhance T cell proliferation as well, and can promote T cell to T helper cells into type I, so dammarane aglycone is a strong immunomodulator aglycones of saponins is not sugar-based parent ring structure, its different physicochemical properties and saponins, aglycones are lipophilic compounds, can be blood-brain barrier.



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