Relaxin is a protein hormone first described in 1926 by Frederick Hisaw.The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence similarity; relaxin-1 (RNL1), 2 (RNL2) and 3 (RNL3), and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6. The functions of relaxin-3, INSL4, INSL5, INSL6 remain uncharacterised.Relaxin is a poorly understood hormone which has been thought to be related to pregnancy since levels rise at that time. Recent research is find that it is involved with many physiologic processes .
Relaxin interacts with the relaxin receptor LGR7 (RXFP1) and LGR8 (RXFP2), which belong to the G protein-coupled receptor superfamily [7]. They contain a heptahelical transmembrane domain and a large glycosylated ectodomain, distantly related to the receptors for the glycoproteohormones, such as the LH-receptor or FSH-receptor.Relaxin receptors have been found in the heart, smooth muscle, the connective tissue, and central and autonomous nervous system.
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Relaxin interacts with the relaxin receptor LGR7 (RXFP1) and LGR8 (RXFP2), which belong to the G protein-coupled receptor superfamily [7]. They contain a heptahelical transmembrane domain and a large glycosylated ectodomain, distantly related to the receptors for the glycoproteohormones, such as the LH-receptor or FSH-receptor.Relaxin receptors have been found in the heart, smooth muscle, the connective tissue, and central and autonomous nervous system.
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