Product
name: 1-Boc-piperazine
A
applied and scalable alertness of 1-(7-fluoronaphthalen-1-yl)-piperazine
hydrochloride (1) is reported. The aboriginal avenue for the amalgam of this
admixture complex the use of 1-amino-7-fluoronaphthalene and
bis(2-chloroethyl)amine hydrochloride, two awful baneful compounds. A new
agreement has been developed that employs a palladium-catalyzed
Buchwald–Hartwig cross-coupling acknowledgment amid 1-Boc-piperazine and
1-bromo-7-fluoronaphthalene followed by piperazine deprotection with HCl gas.
In addition, an able aegis abatement agreement accustomed for the alertness of
the ambition atom with beneath than 20 ppm of this metal. This alignment has
been auspiciously implemented to aftermath multigram quantities of 1 with
accomplished abstention and low aegis content.
Novel
piperazinyl-amide derivatives of N-α-(aryl-sulfonyl)-l-arginine were actinic as
graftable thrombin inhibitors, in the ambience of biomaterials' design. The
accessible agitation of biological action due to a capricious spacer-arm
anchored on the N-4 piperazinyl position and the addition of a trifluoromethyl
accumulation as XPS (X-ray Photoelectron Spectroscopy) tag on the sulfonamide
atom were evaluated in vitro adjoin animal α-thrombin. All the compounds of the
library were begin to be alive at the micromolar level, as the advertence TAME
(N-tosyl-l-arginine methyl ester). The claret compatibilization advance of
poly(ethylene terephthalate) (PET) membrane, coated or grafted by wet allure
analysis with one adumbrative inhibitor of the library, was aswell evaluated,
assuming absorbing abatement in claret array formation.
Molecular
Formula: C9H18N2O2.C2H4O2
Molecular
Weight: 246.31
CAS
Registry Number: 143238-38-4
Melting
point :43-47 ºC
Flash
point: >110 ºC
Synonyms:
tert-Butyl piperazine-1-carboxylate acetate
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