Bicalutamide is marketed by AstraZeneca with the cast names Casodex and Cosudex. It is recommended 50 mg already circadian in aggregate with a luteinizing hormone-releasing hormone alternation or surgical castration.Bicalutamide is an articulate non-steroidal anti-androgen with the empiric blueprint C18H14F4N2O4S and is an fair crumb that is about baffling in water.
Bicalutamide acts as a authentic anti-androgen by bounden to the androgen receptor (AR) and preventing the activation of the AR and consecutive upregulation of androgen acknowledging genes by androgenic hormones. In addition, bicalutamide accelerates the abasement of the androgen receptor. Bicalutamide has been acclimated as a atomic arrangement for the architecture of careful androgen receptor modulators (SARMs) such as Andarine and Ostarine.Bicalutamide is adumbrated for the analysis of date D2 metastatic prostate blight in aggregate with a luteinizing hormone-releasing hormone alternation or as a monotherapy. It has aswell been acclimated in analytic trials for ovarian cancer. It has aswell been acclimated in aggregate with castration.
Most avant-garde prostate blight patients eventually become aggressive to antiandrogen including bicalutamide therapy.Bicalutamide is currently activated for analysis of andogen receptor absolute metastatic breast cancer.Bicalutamide is contraindicated in patients who accept apparent a hypersensitivity acknowledgment to its use. Bicalutamide is a teratogen and have to not be handled by females who are or may become pregnant. It is accepted to could cause fetal harm. pg8 Caution is appropriate if acclimated calm with added medications that depend on CYP3A4 and CYP2D6 metabolisation.
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