The information of thiazole

Appearance: colorless or light yellow, with a special odor, liquid.
Boiling point (℃): 116.8
Relative density (water = 1): 1.20
Flash point (℃): 22
Solubility: slightly soluble in water, soluble in alcohol, ether, and so on.
Main purposes: for synthetic drugs, fungicides, and dyes.
Health hazard: inhalation, ingestion, or dermal absorption harmful to eyes and skin stimulation.
The thiazole contain a sulfur and nitrogen hetero-atom five-membered heterocyclic ring compounds, molecular formula C3H3NS. The yl word from outside the text Last azole transliteration, means a nitrogen-containing five-membered heterocyclic ring, in addition to pyrrole are referred to as a yl. Sulfur and nitrogen accounted for 1,3 two called thiazole; sulfur and nitrogen accounted for 1,2 two, known as the isothiazole. Thiazole and isothiazole not exist in nature. Thiazole with the odor of corruption to light yellow liquid, boiling point 116.8 ° C, the relative density of 1.998 (17/4 ° C). Thiazole and pyridine is similar to a weakly alkaline; to form a salt with picric acid and hydrochloric acid to form complexes with many metal chlorides (such as gold chloride, etc.), and has a melting point of. Department of the thiazole ring has a certain stability, also showed a certain degree of aromaticity. And pyridine are similar in chemical nature, for example, two hydrogen activity; can also generate 2 – aminothiazole with the amino-sodium; its amino diazotization (see diazotization). The thiazole generally can not restore the dihydro and tetrahydro compounds.
Thiazole and its derivatives through a variety of synthesis methods, the common α-halogenated aldehydes or ketones with thioamides were prepared: a variety of thiazole derivatives are important drug or physiologically active substances. Penicillin molecule containing a thiazolidine ring system. Thiazole part of vitamin B1 molecule is a quaternary ammonium derivatives. Current vulcanization accelerator, such as 2 – acetyl thiazole and thiazole derivatives. Important antibacterial agent sulfathiazole 2 – aminothiazole acetamide benzene sulfonyl chloride condensation (see the condensation reaction), then the product obtained by hydrolysis reaction. Thiazole derivatives is the synthesis of amino acids, purine and reagents.
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